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is glutathione can damage kidney Glutathione deficiency alters the vitamin D-metabolizing enzymes CYP27B1 and CYP24A1 in human renal proximal tubule epithelial cells and kidney of HFD-fed mice

Marsoni M251S
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4.7 ★★★★★
Based on 1492 reviews
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Tyler
Omaha, US
★★★★★ 3
Less than 30 min
Color: Blue, Color: Blue
Bought for my 8 month old lab. Dog toy said for aggressive chewers. Wrong! Super cute and feels heavy duty, but not for aggressive chewers.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on January 14, 2025
M
Verified Purchase
M DePriest
Waukegan, US
★★★★★ 5
Good for aggressive chewers!
Color: Blue
Smelled awful out of the package and it's way heavier that I expected, but it's one of the only toys that my puppy has not shredded to pieces.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 8, 2026
S
Verified Purchase
Sarah Snyder
New York, US
★★★★★ 4
Solid Toy NOT For Small Breeds
Color: Blue, Color: Blue
Bought this for my Pug puppy because he's always chewing on our shoes and dragging them outside and in every which direction. He doesn't really damage them, it's more of just a pain to chase him around and try and actually get the shoe from him because he thinks we're playing. So, I looked on Amazon for a shoe toy and found this. It has a decent rating of 4.2 stars currently and it looks pretty sturdy. Well, when I got it, I realized that it's VERY sturdy. In fact, it's too sturdy; at least for a smaller breed like a pug. I know in the title is says for medium to large dogs, but when I looked at the demensions I thought it would be fine for him. He played with it for a few minutes, but it's just too big and VERY heavy for him. I was actually surprised how heavy it was. So, I decided to weigh it on a scale I have and it came out to 0.83 pounds. I actually thought it would read heavier than that (at least a pound), but that's what the scale said and I did it twice to be sure. So, if you have a small dog like a Pug, I wouldn't recommend this. Definitely a great toy for a German Shepherd or something in that category because of how heavy and thick it is. I'm guessing, even with a large breed of dog, this toy is probably going to last a long time. There's also a hole in the top where you can put peanut butter (or some kind if dog friendly treat) inside, which is really cool. I tried that with him as well, but he just wasn't interested. He's more into the Kong plushies. Anyway, in all, it's a pretty good product. Just not for a small breed dog. I'm giving it 4 stars. As you can see from the photos I uploaded, it's a rather small toy, but it's very solid and chunky. I also took a few pictures with a Pilot G2 pen next to it to better judge the size. Would buy from this seller again though if they had other toys for smaller breed dogs. Thank you. 💟 Sarah 💟
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Reviewed in the United States on March 2, 2026
C
Verified Purchase
Courtney
Charlottesville, US
★★★★★ 5
Dog toy
Color: Blue
Great toy for tough chewers
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Reviewed in the United States on May 13, 2026
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Verified Purchase
jennifer langan
Birmingham, US
★★★★★ 1
Smells like chemicals
Color: Blue
Good quality toy but it had a chemical smell. even after washing it my dog wouldn't play with it. Not recommended
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Reviewed in the United States on June 1, 2026

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