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jama glp 1 Genetic differences may help explain why some patients experience greater weight loss or more adverse effects on #GLP1 receptor agonists such as #semaglutide or #tirzepatide, according to a new genome-wide association study

Marsoni M251S
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Frmacos basados en GLP 1: mecanismos implicados en el tratamiento de la obesidad Medicina Clnica After State Health Plan vote, CVS says it seeks lower weight loss drug costs Business North Carolina Professor Ana Santos Rutschman weighed in on recent lawsuits alleging popular GLP 1 drugs can cause serious injuries and how these cases influence public trust, the market and risk warnings for these medications. GLP 1 medications aren't just about weight loss they're changing heart health. Research shows GLP 1s can lower the risk of heart attack and stroke, even for some people without
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4.5 ★★★★★
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Verified Purchase
ryan johnson
Waukegan, US
★★★★★ 5
Tough and sturdy
Size: Medium
Have lasted my dog for years now and she is a tough chewer. Worth the money
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on December 12, 2025
H
Verified Purchase
Hannah Hettasch
Charlottesville, US
★★★★★ 5
Not the most durable, but my dog LOVES it.
Style: Plush Surprise Color, Size: 24"
My boyfriend’s dog had the small version from Petsmart and she has been very gentle with it since she likes it so much. I decided to surprise her with this 24 inch one for Christmas. She was obsessed! It’s cute, it’s very soft, and has a big squeaker in the top, which she loves! She was a little more tough on it and it did get some rips 12 hours in, but it is still in one piece at the moment and brings lots of joy. The dog is a medium/large size. Dog toys can be so expensive. I personally think the was a great price despite not being the most durable. I may purchase again next year!
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Reviewed in the United States on January 3, 2026
D
Verified Purchase
D.G.
Grantham, US
★★★★★ 5
Puppy and price approved!
Style: Latex Surpise Color, Size: 6"
Great cheap little dog toys! Our 11 month large breed 90lb puppy loves to toss these around and squeak them between his teeth.. they eventually break down but that’s okay, at the low price of a couple to a few dollars each they make it affordable. They put some stuffing inside so it makes it slippery when our pup is nibbling on it. Funny enough these last longer than much more expensive toys that claim more durability! In 8 months we’ve gone through 2. That’s pretty good! Not chew resistant, but the latex offers a texture and squeak that I find makes our puppy go easier on them. Cute and easily packable.
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Reviewed in the United States on April 2, 2026
R
Verified Purchase
Roben Wigley
Omaha, US
★★★★★ 5
Very durable dog toy my dog loves it
Style: Latex Surpise Color, Size: 6"
This is turned out to be one of my dogs, favorite toys. She loves it.
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Reviewed in the United States on May 30, 2026
M
Verified Purchase
mrmcc17
San Leandro, US
★★★★★ 4
Dog loves but not durable.
Style: Plush Surprise Color, Size: 24"
Our Golden has gone through 3 of these. He absolutely loves them. Contains two kinds of squeakers and crunchy noise maker. But they don’t last long so it’s good they’re inexpensive. Just wish the fabric was more durable.
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Reviewed in the United States on April 20, 2026

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