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GLP 1 receptor agonists are increasingly used to treat type 2 diabetes and obesity, and trials have shown reductions in cardiovascular risk and slowing of kidney failure. Adverse events are mostly gastrointestinal. Beyond GLP1: modulating multiple nutrient stimulated hormone pathways to reduce cardiovascular risk Nature Reviews Cardiology GLP 1R activation attenuates the progression of pulmonary fibrosis via disrupting NLRP3 inflammasome PFKFB3 driven glycolysis interaction and histone lactylation Journal of Translational Medicine Springer Nature Link Risks of Ozempic, other GLP 1 drugs are at center of sweeping lawsuit that kicked off in Philadelphia Pittsburgh Post Gazette
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