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67,000 people on semaglutide (Wegovy) or tirzepatide (Mounjaro). 410,198 Reddit posts. Analysed by the University of Pennsylvania and published in Nature Health, April 2026. 43.5% reported at least one side effect. The
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University of Pennsylvania researchers analyzed over 400,000 Reddit posts from nearly 70,000 users across five years and found that semaglutide and tirzepatide users are reporting menstrual irregularities and temperature complaints like chills
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side effects of Ozempic (semaglutide), a GLP-1 receptor agonist widely used for the management of type 2 diabetes mellitus and for weight loss. Common side effects—primarily gastrointestinal—include nausea, vomiting, diarrhea, constipation, abdominal
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