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What is the difference between semaglutide (Ozempic, Wegovy, Rybelsus) and tirzepatide (Mounjaro) in metabolic outcomes and mechanism? How did we find out diabetes medications can help with weight loss? What impact do In an earlier analysis of the SURMOUNT 1 trial, tirzepatide (a dual glucose dependent insulinotropic polypeptide [GIP] and glucagon like peptide 1 [GLP 1] receptor agonist) was shown to provide substantial and sustained reductions in body weight Real world data from a Cleveland Clinic study showed GLP1 therapies (semaglutide, tirzepatide) led to a mean 8.7% weight loss at one yearbut over 50% of patients discontinued early due to cost, side In patients with type 2 diabetes and atherosclerotic cardiovascular disease, tirzepatide was noninferior to dulaglutide with respect to major cardiovascular events. Full SURPASS CVOT trial results: https: nej.md 4qd5rLx
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