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Tirzepatide: In the SURMOUNT-1 trial, weight reduction percentages were dose-dependent: 5 mg: ~15.0% weight reduction. 10 mg: ~19.5% weight reduction. 15 mg: ~20.9% weight reduction (Jastreboff et al., 2022). https://www.nejm.org/doi/10.1056
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In the SURMOUNT-4 trial, 82.5% of adults with obesity regained ≥25% of initial weight lost within one year of tirzepatide withdrawal; most showed reversal of cardiometabolic improvements. https://ja.ma/4qaMLfO
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SURMOUNT-1: In an RCT, adults with obesity treated with weekly tirzepatide had major weight loss over 72 weeks. #ADA2022 https://t.co/X2RrvYxzsV
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In the SURMOUNT-4 trial, 82.5% of adults with obesity regained ≥25% of initial weight lost within one year of tirzepatide withdrawal; most showed reversal of cardiometabolic improvements. https://ja.ma/4qaMLfO
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STEP 1 (NEJM 2021) showed that semaglutide 2.4 mg once weekly produced a mean weight loss of 14.9% in 1,961 adults with obesity — with 1 in 3 participants losing over 20%
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