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A large-scale analysis of Reddit data identifies symptoms—including fatigue and menstrual changes—frequently missed in clinical trials. These real-world patient insights highlight a broader spectrum of physiological responses to semaglutide and
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67,000 people on semaglutide (Wegovy) or tirzepatide (Mounjaro). 410,198 Reddit posts. Analysed by the University of Pennsylvania and published in Nature Health, April 2026. 43.5% reported at least one side effect. The
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Has anyone switched *from* tirzepatide to semaglutide (or anything else)? : r/slowresponders
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Penn Researchers Use AI to Surface Unreported GLP-1 Side Effects in Reddit Posts
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