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semaglutide vs tirzepatide vs retatrutide Retatrutide vs Tirzepatide vs Semaglutide: The Scientific Showdown of GLP-1 Agonists (2025)

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4.2 ★★★★★
Based on 2330 reviews
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B
Verified Purchase
B Helton
Belleville, US
★★★★★ 1
PLEASE REVIEW — FORMULA CHANGED!!!
I wish I would’ve posted a review PRIOR to the formula changing but just know that I LOVED this serum. I’ve struggled with hormonal acne (PCOS) and eczema for as long as I can remember. Finally, last summer my dermatologist put me on (3) different RX including Spironolactone and Accutane. I was so tired so I stopped everything except for CeraVe cleanser, retinol (Tretinoin) and CeraVe healing ointment. My made up skin routine was working until I used too much Tretinoin and burned my face. I had read great reviews about this product so I thought, I might as well try it — and IT WORKED! I’ve been using this product for almost a year and I loved it. However, 3 weeks ago when I ordered it, I noticed the bottle had a green tint. I could tell after one use that the feel of the serum was different, more watery, not as thick as it used to be. The smell was also different. Still, I kept using it for nearly 2 weeks and I experienced 2 breakouts! Sure enough, I stopped the product and within a few days, my skin was back to normal. I am very upset because as someone who has extremely sensitive skin, this worked but unfortunately, the new formula isn’t for me.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 14, 2026
C
Verified Purchase
candi muncy
Lexington, US
★★★★★ 5
Great for post microneedling or tattoos
Size: 1.3 Fl Oz (Pack of 1)
Great for skin after microneedling. Keeps skin feeling smooth, non-greasy
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 21, 2026
Y
Verified Purchase
Yo-Landa
Boise, US
★★★★★ 5
Good on my Melanated skin
Size: 1.3 Fl Oz (Pack of 1)
Lovely, just wish it was bigger or cheaper but I love it and will buy again
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 11, 2026
F
Verified Purchase
Francophile
Massapequa, US
★★★★★ 5
Feels good on the skin not greasy
Size: 1.3 Fl Oz (Pack of 1)
Very nice product very concentrated has a very light fragrance that dissipates very quickly not greasy. No I do not have any redness or sensitivity I wanted to try this product anyway because I'm always looking for moderately priced good quality that travels well. And this fit the bill especially with it being on sale.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on January 8, 2026
M
Verified Purchase
Marina Gulley
Boise, US
★★★★★ 4
Good product , but
Size: 1.3 Fl Oz (Pack of 1), Size: 1.3 Fl Oz (Pack of 1)
It seems to be a good product and it’s not too heavy , but still caused few breakouts here and there . Also, Avenue always has protective foil on their cream , this one didn’t have (I replaced it but new one also didn’t have it). Also, it goes away really fast because it’s only 1.3 ounces.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 12, 2026

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