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A first-in-human study suggested that tirzepatide — a dual GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) receptor agonist — modulated abnormal activity in the brain's nucleus accumbens, thereby reducing food cravings and inducing
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In a patient taking bupropion 100 mg daily, buspirone 1 mg nightly, tirzepatide 2.5 mg weekly, rosuvastatin 5 mg every other day, ezetimibe 10 mg daily, ibuprofen as needed, baclofen 5–10 mg
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