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Mounjaro (tirzepatide) is a dual incretin agonist targeting both GLP 1 and GIP receptors. It improves glycaemic control by enhancing insulin secretion, suppressing glucagon, and delaying gastric emptying which also leads to Oral GLP 1 Based Therapeutics in the ObesityMetabolic SyndromeDiabetes Continuum: Translational Advances, Clinical Barriers, and Emerging Strategies 24.2% body weight lost at 48 weeks. Not by eating less. By burning more at rest. Retatrutide is a triple agonist: a single synthetic peptide that simultaneously engages three receptors GLP 1R, Dipeptidyl Peptidase 4 Inhibitors: Novel Therapeutic Agents in the Management of Type II Diabetes Mellitus Aloke 2025 Pharmacoepidemiology and Drug Safety Wiley Online Library
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